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KMID : 0377519940190030279
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Chung-Ang Journal of Medicine
1994 Volume.19 No. 3 p.279 ~ p.292
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Time-Dependent Pattern of Cadmium(Total-, MT bound-and Free-) Distribution in Liver and Kidney
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Abstract
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To investigate the pattern of cadmium(Cd) distribution in liver and kidney, Sprague-Dawley male rats were treated which cadmium chloride solution of 0.8, 1.6, 2.4mg/kg by single intravenous injection. Cd-treated rats were sacrificed at 12, 24,
48,
168
and 672 hours after injection. Total-and MT-Cd concentrations were analysed using atomic absorption spectrophotometery by flameless method, and free-Cd concentration was calculated by subtacting MT-Cd from total-Cd.
Total Cd concentrations of liver and kidney were increased in proportion to dose of cadmium, while tended to decrease since 12 hours after Cd exposure in liver, but to increase with time after Cd exposure in kidney. Total Cd concentrations of
liver
and
kidney were able to estimate according to dose(mg CdCl2/kg) and time(hour) after injection of cadmium as the following multiple linear regressions:
Cd L=1.5471-0.0013T+5.8108D(F=199.8, R=0.9215, n=74, p<0.01)
Cd K=-1.6376+0.0056T+2.7372D(F=94.0, R=0.8520, n=74, p<0.01).
Total Cd concentration was higher in liver than in kidney. The difference of total Cd between liver and kidney was decreased with time after exposure, this finding suggests an assumption that hepatic Cd was transported to kidney. Tissue total Cd
concentration between liver and kidney was well correlated. Dose- and Time-dependent patterns of MT-Cd and free Cd were similar to total Cd of liver and kidney. The proportion of MT-Cd to total-Cd was higher in liver than in kidney. This findings
suggests that Cd-induced MT synthesis is higher in liver than in kidney.
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KEYWORD
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